ObjectiveTo explore the effects of aspirin combined with clopidogrel on the blood rheology and intracranial hemodynamics in patients with worsening cerebral infarction (WCI).

MethodsNinety-two patients with WCI were divided into the combination group (n=46) and control group (n=46).The control group was treated with the conventional treatment combined with aspirin, and the combination group was treated with conventional treatment combined with aspirin and clopidogrel for two courses.

ResultsBefore treatment, the differences of the blood rheology indicators, middle cerebral artery (MCA), anterior cerebral artery (ACA) and posterior cerebral artery (PCA), thromboelastography and National Institutes Health Stroke scale (NIHSS) score between two groups were not statistically significant (P>0.05), but the difference of whole blood viscosity between two groups was statistically significant (P < 0.01).After treatment, the whole blood viscosity, plasma viscosity, hematocrit, fibrinogen, MCA, ACA and PCA significantly decreased in two groups (P < 0.05), the whole blood viscosity, plasma viscosity, hematocrit, MCA, The ACA, PCA, M, Ma, α angle and NIHSS score in combination group were lower than those in control group (P < 0.05).The latency time between the initiation of coagulation and formation of blood clot in combined group was higher than that in control group (P < 0.05), and the results of DSA showed that the arterial stenosis in the combination group had been significantly alleviated.There was no statistical significance in total blood viscosity and fibrinogen between two groups (P>0.05).The adverse reactions in two groups were mild, no intracranial hemorrhage or gastrointestinal bleeding were found (P>0.05).

ConclusionClopidogrel combined with aspirin in the treatment of WCI is helpful to improve the blood flow, reduce the risk of thrombosis, further prevent the stenosis of intracranial artery congestion, and improve the neural function of patients.