Abstract:
Objective:To evaluate the effect of dexmedetomidine(DEX) on the hemodynamic changes induced by scalp infiltration with epinephrine-lidocaine mixture during craniotomy under general anesthesia.
Methods:One hundred patients with intracranial tumor were randomly and equally divided into five groups, and each group was infiltrated 16 ml of epinephrine-lidocaine mixture of different concentrations:group A 2.5 μg/ml, group B 5 μg/ml, group C 7.5 μg/ml, group D 10 μg/ml and group E 7.5 mg/ml received intravenous pumping of DEX 1 μg/kg before scalp infiltration.The hemodynamic changes were recorded before anesthetic induction, infiltration, using DEX and 5 min after infiltration.
Results:The number of the patients with declined mean arterial pressure(MAP) over 20% was greater in group C than that in group D(
P<0.05).The MAP and systolic blood pressure(SBP) had no statistically significant difference among the five groups in T
base values and T
0(
P>0.05).The SBP in group E on T
1, T
2, and T
7~T
10 was higher than that on T
0(
P<0.05 to
P<0.01);and compared with group C, the SBP on T
1~T
5, T
8~T
9, the diastolic blood pressure(DBP) on T
1 and T
3~T
10, and the MAP on T
1~T
10 had significant differences(
P<0.05);the DBP, MAP and heart rate of group E had no significant differences at different time-points(
P>0.05).
Conclusions:The epinephrine-lidocaine mixture used for scalp infiltration could reduce the arterial pressure of the patients undergoing craniotomy;intravenous pumping of DEX could attenuate the hypotension degree induced by scalp infiltration of epinephrine-lidocaine mixture.