Abstract: Objective:To explore the nasal mucosal morphology changes of chronic rhinosinusitis after operation and its correlation.Methods:Sixty patients with chronic rhinosinusitis and 30 healthy examination people were divided into the observation group and control group, respectively.The observation group were subdivided into the infection group and allergy group according to the clinical symptoms and pathological types.The observation group were treated with conventional Messerklinger endoscopic sinus surgery.The postoperative curative effects and nasal mucosa morphology in observation group were observed, and the correlative factors of influencing nasal mucosa recovery were analyzed.Results:The treatment effective rate in infection group(96.67%) was significantly higher than that in allergy group(63.33%)(P<0.01).The difference of nasal mucosa morphology between the infection group and allergy group before treatment was not statistically significant(P>0.05), the nasal mucosa morphology in infection group after treatment was better than that in allergy group(P<0.05 to P<0.01).Conclusions:The nasal mucosal morphology after endoscopic sinus surgery improves significantly, and its recovery is correlated to the pathological type.