Abstract: Objective: To build the stereotactic data set and the planar regression equation of cerebral precentral sulcus,based on the Descartes coordinate system which was set on the line between the anterior commissure and the posterior commissure(AC-PC).Methods: Through the strict image registration,the coordinate system of the software coincides with the Descartes coordinate system based on AC-PC line were made.The X-value and Y-value of sample points were measured and recorded,which were begun from the outermost points to the medial of the X-axis and were taken absolute value of X for 3 mm multiple points as sampling points along the precentral sulcus line.The Z-value of sample points were measured the distances that from every recorded plane to the AC-PC plane.The stereotactic data set of the precentral sulcus were constituted with all the coordinate values of sample points,then the regression equations were fetched and analyzed using the SPSS19.0 software.Results: The three-dimensional stereotactic data set and the regression equation of the cerebral precentral sulcus were constructed successfully.Conclusions: The construction of cerebral precentral sulcus stereotactic data set is expected to have fairly clinical value in neurosurgery,micro-surgery and interventional radiotherapy of lesions in the adjacent areas of precentral sulcus.Meanwhile,this study is of definite significance to anthropology and physique surveying.