腹型肥胖与动脉粥样硬化及外周动脉疾病相关性研究

    Correlations of abdominal obesity with atherosclerosis and peripheral arterial disease

    • 摘要: 目的: 探讨腹型肥胖与动脉粥样硬化及外周动脉疾病的相关性。方法: 将118例内分泌科门诊、住院患者以及健康体检中心体检人群,以腰围/身高比值(WHtR)=0.5为界分为腹型肥胖组(AO组,WHtR≥0.5)64例,非腹型肥胖组(NAO组WHtR<0.5)54例,分别分析WHtR与颈动脉内膜中层厚度(CIMT)及踝臂指数(ABI)的关系。结果: AO组较NAO组体质量指数、腰围、收缩压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、尿酸及CIMT均增高(P<0.05~P<0.01),而ABI及高密度脂蛋白胆固醇均显著降低(P<0.01)。多元线性回归分析显示,WHtR是CIMT和ABI的独立危险因素。Logistic回归分析显示,AO组发生动脉粥样硬化和外周动脉病变的危险分别是NAO组的3.48倍(95%CI=1.389~9.941,P<0.01)和2.27倍(95%CI=1.061~3.132,P<0.01)。结论: 与NAO组相比,AO组发生动脉粥样硬化性和外周动脉病变的风险显著增高,腹型肥胖作为心血管疾病的危险因素应越来越受到重视。

       

      Abstract: Objective: To investigate the correlations of abdominal obesity with atherosclerosis and peripheral arterial disease.Methods: One hundred and eighteen cases from outpatient department of endocrinology department and physical examination people were divided into the abdominal obesityAO group,waist to height ratio(WHtR)more than or equal to 0.5,64 cases and no abdominal obesityl NAO group,WHtR less than 0.5,54 cases) according to the value of WHtR.The correlations of WHtR,and carotid intima-media thickness(CIMT) and ankle-brachial index(ABI) were analyzed.Results: Compared with the NAO group,the body mass index,waist circumference,systolic blood pressure,triglyceride,total cholesterol,low density lipoprtein cholestorol and CIMT in AO group significantly increased(P<0.05 to P<0.01),but their high density lipoprotein cholesferol and ABI levels decreased significantly(P<0.01).Multiple linear regression analysis showed that WHtR was the independent risk factor for CIMT and ABI.Multiple logistic regression analysis showed that the morbidities of atherosclerosis and peripheral arterial disease in AO group were 3.48 times(95%CI=1.389 to 9.941,P<0.01) and 2.27 times(95%CI=1.061 to 3.132,P<0.01) against the NAO group,respectively.Conclusions: The morbidities of atherosclerosis and peripheral arterial disease in people with abdominal obesity are significantly higher than those in people without abdominal obesity.The risk factor of cardiovascular disease should be paid attention to.

       

    /

    返回文章
    返回