Abstract: Objective:To explore the management skills of ureteroscope and handling the accidents strategy.Methods:The clinical data of 956 patients with ureteral calculi treated with Holmium laser lithotripsy under ureteroscope were retrospectively analyzed.Results:The ureteroscope operations in 103 cases were difficulty,which included 56 cases with ureterostenosis(including the ureter opening stricture in 16 cases,mild ureteral stenosis in 26 cases,segment ureteral stricture in 5 cases and ureteral stricture ring in 9 cases),35 cases with ureter twist,4 cases with the opening blocked by ureter stone,2 cases with no ureter opening because of cystitis(pelvic lipomatosis),2 cases with ureteropelvic atresia,2 cases with prostatic hyperplasia complicated with more prostate tissue breaking into the bladder,1 case with renal pelvis perforation caused by placing double J tube and 1 case with open surgery because of the placing double J tube failure.Conclusions:The ureteral stenosis and distortion are usually problems in ureteroscope operation,which can be settled by guiding catheter dilatation,increasing water pressure,changing position,replacing fine ureteroscope and exchanging the angle of ureteroscope.open surgery is the effective measure to correct error.