Abstract: Objective:To investigate the prediction value of peripheral blood procalcitonin(PCT) levels in the prognosis evaluation of patients with heart failure with preserved ejection fraction(HFPEF).Methods:One hundred and twenty-five patients with HFPEF were enrolled.Serum PCT levels were monitored,and the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score,sequential organ failure assessment(SOFA) score were recorded at the 1st,2nd,3rd and 5th day.According to the 14-day outcome after admission,the patients with HFPEF were divided into survivor group and non-survivor group,the dynamic changes of serum PCT levels,APACHE Ⅱ score and SOFA score were compared between the two groups and the correlation analysis was carried out.Results:There was no significant difference in serum PCT levels at the 1st and 2nd day between survivor group and non-survivor group(P >0.05),but the positive statistical correlation was found between serum PCT levels and APACHE Ⅱ score,SOFA score in non-survivor group(P<0.01).Receiver operator characteristic curve revealed serum PCT levels on the 3rd day could significantly predict the 14-day mortality,maximal area under the curve of serum PCT was 0.815.Conclusions:Dynamic monitoring of serum PCT levels could help to assessment the prognosis of patients with HFPEF,also to predict the severity of the illness.