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    马铭, 袁耀宗, 刘建生, 田怡, 张晓红, 刘海玲. 重组人生长激素联合支链氨基酸对肝硬化患者肿瘤坏死因子-α和白细胞介素-10的影响[J]. 蚌埠医科大学学报, 2015, 40(3): 357-358,361. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.020
    引用本文: 马铭, 袁耀宗, 刘建生, 田怡, 张晓红, 刘海玲. 重组人生长激素联合支链氨基酸对肝硬化患者肿瘤坏死因子-α和白细胞介素-10的影响[J]. 蚌埠医科大学学报, 2015, 40(3): 357-358,361. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.020
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    MA Ming, YUAN Yao-zong, LIU Jian-sheng, TIAN Yi, ZHANG Xiao-hong, LIU Hai-ling. Effect of recombinant human growth hormone combined with branched chain amino acid on the levels of tumor necrosis factor-α and interleukins-10 in patients with hepatic cirrhosis[J]. Journal of Bengbu Medical University, 2015, 40(3): 357-358,361. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.020
    Citation: MA Ming, YUAN Yao-zong, LIU Jian-sheng, TIAN Yi, ZHANG Xiao-hong, LIU Hai-ling. Effect of recombinant human growth hormone combined with branched chain amino acid on the levels of tumor necrosis factor-α and interleukins-10 in patients with hepatic cirrhosis[J]. Journal of Bengbu Medical University, 2015, 40(3): 357-358,361. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.020
    shu

    重组人生长激素联合支链氨基酸对肝硬化患者肿瘤坏死因子-α和白细胞介素-10的影响

    Effect of recombinant human growth hormone combined with branched chain amino acid on the levels of tumor necrosis factor-α and interleukins-10 in patients with hepatic cirrhosis

      摘要
    • 摘要: 目的:探讨重组人生长激素(r-hGH)联合应用支链氨基酸(BCAA)对肝硬化失代偿期患者肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的影响。方法:将82例肝硬化失代偿期患者随机分为治疗组42例和对照组40例。在相同保肝、支持治疗基础上,治疗组应用r-hGH 5 IU,每2天1次皮下注射,同时联用BCAA 250 ml,每天1次静脉滴注,连用20 d。对照组应用BCAA 250 ml,静脉滴注,每天1次,连用20 d。观察治疗前和治疗结束后第2天患者肝功能和TNF-α、IL-10水平变化情况。结果:2种治疗方法对患者肝功能指标、血清TNF-α和IL-10水平均有改善,但治疗组在纳差、下肢水肿等症状改善及丙氨酸氨基转移酶、白蛋白和血清TNF-α、IL-10水平改善方面均优于对照组(P<0.05～P<0.01)。结论:r-hGH联合BCAA在改善患者血清白蛋白和改善TNF-α、IL-10水平等方面优于单纯应用BCAA。

       

      Abstract: Objective:To investigate the effects of recombinant human growth hormone(r-hGH) combined with branched chain amino acid(BCAA) on the levels of Tumor necrosis factor-α(TNF-α) and interleukins-10(IL-10) in patients with decompensated cirrhosis.Methods:Eighty-two patients with decompensated cirrhosis were randomly divided into the treatment group(42 cases) and control group(40 cases).The treatment group and control group were treated with 5 IU of r-hGH by subcutaneous injection 1 time two days combined with 250 ml of BCAA by intravenous drip once a day for 20 d and 250 ml of BCAA by intravenous drip once a day for 20 d based on protecting liver and support treatment,respectively.The liver function and levels of TNF-α and IL-10 in two groups were observed before and after treatment.Results:The liver function and levels of TNF-α and IL-10 in two groups were improved,the improvement of poor appetite,lower limbs edema,and the levels of alanine aminotransferase,albumin,TNF-α and IL-10 in treatment group were better than those in control group(P<0.05 to P<0.01).Conclusions:The effects of r-hGH combined with BCAA on the improvement of serum albumin,TNF-α and IL-10 levels are better than those of BCAA alone.

       

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