Abstract: Objective:To explore the protective effects of Acanthopanax senticosus injection on the acute alcoholic hepatic injury in mice.Methods:Sixty Kunming male mice(18 to 22g) were randomly divided into the normal group, model group, Tiopronin positive control group, and Acanthopanax senticosus injection high, medium and low dose group(200 mg/kg, 100 mg/kg and 50 mg/kg)(10 mice each group).The alcoholic hepatic injury model of mice was established by intragastric administration with 12 ml/kg/d of 50% alcohol for 10 days.The levels of serum aspartate transaminase(AST), alanine transferase(ALT), Triglyceride(TG), liver tissue malondialdehyde(MDA) and Glutathione in all groups were detected.Liver index and hepatic pathological changes in all mice were calculated and observed, respectively.Results:The alcoholic hepatic injury model of mice was successfully established.Acanthopanax senticosus injection could reduce the levels of AST, ALT and TG, inhibit the increase of liver MDA, improve the content of reduced glutathione in liver(P<0.05~P<0.01), decrease the liver index and alleviate the liver tissue injury(P<0.05 and P<0.01).Conclusions:Acanthopanax senticosus injection can protect the alcoholic hepatic injury of mice, and the mechanism of which may be related to the suppressing oxidative stress.