Abstract: Objective:To explore the effects of the target-controlled infusion(TCI) of remifentanil on the cardiovascular reaction during general anesthesia recovery period.Methods:Sixty ASAⅠ-Ⅱ patients scheduled by lumber operation were randomly divided into the remifentanil group(group R, 30 cases) and control group(group C, 30 cases).The 4 ng/ml of remifentanil was continuously injected into the group R by TCI from the end of operation to the tracheal extubation, the injection of remifentanil in group C stopped at the end of operation.The blood pressure, heart rate, the time of breath recovery and extubation, move restlessly and bucking and the number of patients with bad memories in two groups before anesthesia(T₁), at the time of extubation(T₂), and after 1 min(T₃), 3 min(T₄), and 5 min(T₅) of extubation were recorded.Results:Compared with the group R, the blood pressure and heart rate in group C were significantly increased at T₂, T₃, T₄ and T₅(P<0.01), the incidence rate of move restlessly and bucking in group C at waking up was significantly increased(P<0.01).The differences of the time of breath recovery and extubation between two groups were not statistically significant(P>0.05).The number of patients with bad memories in group C after extubation were significantly higher than those in group R(P<0.01).Conclusions:The treatment of 4 ng/ml of remifentanil by TCI can effectively relieve the cardiovascular reaction during general anesthesia recovery period, steady bloodstream dynamics and improve the comfort level of patients.