Abstract: Objective: To explore the clinical effects of Montelukast in the treatment of cough-variant asthma in children.Methods: One hundred and five children with cough-variant asthma were randomly divided into the routine treatment group(56 cases) and Montelukast treatment group(49 cases).The routine treatment group were treated with inhaled corticosteroids for a long time,oral beta 2 receptor agonists for a short time combined with antiallergy,antitussive and expectotating phlegm,the Montelukast treatment group were treated with Montelukast(4 to 5 mg each time,once a day,by half after 3 months for 6 months) based on the routine treatment.The effects between two groups were compared after 2 weeks and 6 months of treatment.Results: After 2 weeks of treatment,the effective rate in Montelukast treatment group(71.43%) was higher than that in routine treatment group(50.00%)(P<0.01).After 6 months of treatment,the effective rate in Montelukast treatment group were 91.84%,which was significantly higher than that in routine treatment group(69.64%)(P<0.01),and no obvious adverse reaction was observed in Montelukast treatment group.Conclusions: Whether short-term or long-term oral treatment,Montelukast can obviously improve the treatment effects of cough-variant asthma in children,especial for the long-term treatment.