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    牛海军, 吴桥, 江荣炎, 卜令同. 血浆脂蛋白a、高敏C反应蛋白、脑钠肽水平与冠状动脉病变程度的相关性研究[J]. 蚌埠医科大学学报, 2015, 40(5): 629-632. DOI: 10.13898/j.cnki.issn.1000-2200.2015.05.023
    引用本文: 牛海军, 吴桥, 江荣炎, 卜令同. 血浆脂蛋白a、高敏C反应蛋白、脑钠肽水平与冠状动脉病变程度的相关性研究[J]. 蚌埠医科大学学报, 2015, 40(5): 629-632. DOI: 10.13898/j.cnki.issn.1000-2200.2015.05.023
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    NIU Hai-jun, WU Qiao, JIANG Rong-yan, BU Ling-tong. The correlation between the levels of the plasma lipoprotein(a),high sensitive C-reactive protein and brain natriuretic peptide with the severity of coronary artery disease[J]. Journal of Bengbu Medical University, 2015, 40(5): 629-632. DOI: 10.13898/j.cnki.issn.1000-2200.2015.05.023
    Citation: NIU Hai-jun, WU Qiao, JIANG Rong-yan, BU Ling-tong. The correlation between the levels of the plasma lipoprotein(a),high sensitive C-reactive protein and brain natriuretic peptide with the severity of coronary artery disease[J]. Journal of Bengbu Medical University, 2015, 40(5): 629-632. DOI: 10.13898/j.cnki.issn.1000-2200.2015.05.023
    shu

    血浆脂蛋白a、高敏C反应蛋白、脑钠肽水平与冠状动脉病变程度的相关性研究

    The correlation between the levels of the plasma lipoprotein(a),high sensitive C-reactive protein and brain natriuretic peptide with the severity of coronary artery disease

      摘要
    • 摘要: 目的:探讨血浆脂蛋白aLp(a)、高敏C反应蛋白(hs-CRP)、脑钠肽(BNP)水平与冠状动脉病变程度的相关性。方法:将216例行冠状动脉造影患者根据造影结果分为冠心病组129例(包括单支病变组35例、双支病变组40例和三支病变组54例)和对照组87例。分别检测各组患者血浆Lp(a)、hs-CRP、BNP水平,并分析其与冠状动脉病变支数及Gensini评分的相关性。结果:冠心病组患者血浆Lp(a)、hs-CRP和BNP水平均明显高于对照组(P<0.01)。不同病变支数各组血浆Lp(a)、hs-CRP、BNP水平差异均有统计学意义,其中三支病变组均明显高于对照组及单支病变组(P<0.01)。随着Gensini评分升高,血浆Lp(a)、hs-CRP和BNP水平也随之升高(P<0.01)。冠心病组血浆Lp(a)、hs-CRP和BNP水平与冠状动脉病变支数及冠状动脉Gensini评分均呈正相关关系(P<0.01)。结论:联合检测血浆Lp(a)、hs-CRP、BNP水平对判断冠状动脉病变程度具有指导意义。

       

      Abstract: Objective: To explore the correlation between the levels of the plasma lipoprotein(a)Lp(a),high sensitive C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) with the severity of coronary artery disease(CAD).Methods: According to the results of coronary angiography,216 patients were divided into the CAD group(216 cases) and control group(87 cases),and the CAD group were subdivided into the single-vessel disease group(35 cases),double-vessel disease group(40 cases) and three-vessel disease group(54 cases).The levels of the plasma Lp(a),hs-CRP and BNP in all groups were detected,and the correlations of whose with coronary lesion vessels and Gensini scores were analyzed.Results: The levels of Lp(a),hs-CRP and BNP in CAD group were significantly higher than those in control group(P<0.01).The differences of the levels of Lp(a),hs-CRP and BNP in different vessels disease group were statistically significant(P<0.01),and the levels of Lp(a),hs-CRP and BNP in three-vessel disease group were significantly higher than those in control group and single-vessel disease group(P<0.01).With the increasing of Gensini score,the levels of plasma Lp(a),hs-CRP and BNP increased(P<0.01).There was a positive correlation between the levels of Lp(a),hs-CRP and BNP with coronary lesion vessels and Gensini scores(P<0.01).Conclusions: The combined detection of the levels of plasma Lp(a),hs-CRP and BNP has an important significance in judging the severity of coronary artery disease.

       

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