Abstract: Objective:To investigate the therapeutic efficacy of the total and proximal gastrectomy in the treatment of adenocarcinoma of the esophagogastric junction(AEG).Methods:Forty-three patients with advanced adenocarcinoma of the esophagogastric junction were randomly divided into the total gastrectomy group(TG group, 22 cases) and proximal gastrectomy group(PG group, 21 cases).The average operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and postoperative 1 and 2-year survival rates between two groups were compared.Results:The differences of the operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and 1-year survival rate between two groups were not statistically significant(P>0.05), the difference of the 2-year survival rate between two groups was statistically significant(P<0.05).Conclusions:The total gastrectomy for treating the patients with advanced adenocarcinoma of the esophagogastric junction can increase their postoperative survival time, decrease their incidence of complications and improve their living quality, which is an ideal operation method.