儿童特发性血小板减少性紫癜淋巴细胞亚群变化

张兰芳; 胡正; 山浩明

doi:10.13898/j.cnki.issn.1000-2200.2015.06.033

儿童特发性血小板减少性紫癜淋巴细胞亚群变化

Change of lymphocyte subsets in children with idiopathic thrombocytopenic purpura

摘要

摘要: 目的:儿童分析特发性血小板减少性紫癜(ITP)外周血淋巴细胞亚群的变化。方法:应用流式细胞术, 分别检测85例ITP患儿(ITP组)和32名健康体检儿童(对照组)淋巴细胞亚群。结果:与对照组相比, ITP组患儿外周血CD3⁺和CD4⁺细胞数量减少, CD4⁺／CD8⁺比值下降(P<0.01);CD8⁺细胞与对照组差异无意义(P>0.05)。CD19⁺细胞较对照组明显增多, CD16⁺CD56⁺细胞较对照组减少(P<0.01)。结论:ITP患儿淋巴细胞亚群与正常儿童存在差异, 淋巴细胞亚群紊乱是儿童ITP发生的免疫机制之一。

Abstract: Objective:To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura(ITP).Methods:The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry.Results:The percentages of CD3⁺ and CD4⁺ and the ratio of CD4/CD8 in ITP group were lower than those in control group(P<0.01), and the difference of CD8⁺ lymphocyte between two groups was not statistically significant(P>0.05).Compared with the control group, the number of CD19⁺ and CD16⁺CD56⁺ lymphocytes in ITP group increased and decreased, respectively, the differences of whose between two groups were statistically significant(P<0.01).Conclusions:The disorder of lymphocyte subsets is one of the immune mechanism of ITP occurrence in children.Correcting disorder will be conducive to the treatment.

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