Abstract: Objective:To investigate the safety and efficacy of dexmedetomidine(DEX)assisting anesthesia in children with tonsillectomy.Methods:Sixty children treated with tonsillectomy were randomly divided into the DEX assisting anesthesia group(DEX group) and the regular anesthesia group(control group)(30 cases in each group).The DEX group and control group were treated with 1 μg/kg of DEX and 0.9% sodium chloride injection by microinjection pump,respectively.The mean arterial pressure and heart rate in two groups were observed before injection,10 min after injection,the beginning of operation and end of operation.The amount of bleeding and consumption of fentanyl,respiratory depress,nausea and vomiting in two groups were recorded.Results:The efficacy of anesthesia in DEX group was better than that in control group(PPPConclusions:DEX assisting anesthesia can be used in tonsillectomy children,the good analgesia and sedation effects,stable circulation,quick palinesthesia and without respiratory depression are found.