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    朱云琳, 程新德, 梅娟, 马红丽, 张莉. 不同剂量川芎嗪对兔背缺血皮瓣的作用[J]. 蚌埠医科大学学报, 2015, 40(8): 992-994. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.002
    引用本文: 朱云琳, 程新德, 梅娟, 马红丽, 张莉. 不同剂量川芎嗪对兔背缺血皮瓣的作用[J]. 蚌埠医科大学学报, 2015, 40(8): 992-994. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.002
    shu
    ZHU Yun-lin, CHENG Xin-de, MEI Juan, MA Hong-li, ZHANG Li. The effect of different dosages of ligustrazine on the ischemic skin flap of rabbit back[J]. Journal of Bengbu Medical University, 2015, 40(8): 992-994. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.002
    Citation: ZHU Yun-lin, CHENG Xin-de, MEI Juan, MA Hong-li, ZHANG Li. The effect of different dosages of ligustrazine on the ischemic skin flap of rabbit back[J]. Journal of Bengbu Medical University, 2015, 40(8): 992-994. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.002
    shu

    不同剂量川芎嗪对兔背缺血皮瓣的作用

    The effect of different dosages of ligustrazine on the ischemic skin flap of rabbit back

      摘要
    • 摘要: 目的:寻找川芎嗪对缺血皮瓣发挥保护作用的合适剂量。方法:家兔16只随机分为4组,于兔背部设计8 cm×2 cm任意皮瓣,切取、剥离后原位缝合。对照组(A组)予以0.9%氯化钠注射液4 ml/kg,术后用药组分别予以川芎嗪15、30、60 mg/kg(B、C、D组)。术后第7天处死白兔,测量皮瓣成活面积,分析不同剂量的川芎嗪与皮瓣成活之间的关系。结果:术后第7天皮瓣远端均发生坏死,近端成活。随药物剂量增加,C、D组皮瓣成活面积及成活率均高于A、B组(P<0.05～P<0.01);A组与B组和C组与D组皮瓣成活面积及成活率差异均无统计学意义(P>0.05)。结论:适当剂量使用川芎嗪治疗可提高局部缺血皮瓣的成活率。

       

      Abstract: Objective:To investigate the suitable dosages of ligustrazine with good protective effect on ischemic skin flap.Methods:The Japanese big ear white rabbits were randomly divided into four groups.The 8 cm×2 cm random flap in the rabbit back was designed,cut and stripped,and the rabbits were stitched in situ.Group B,C and D were treated with 15,30 and 60 mg/kg of ligustrazine after operation,respectively,and the group A were treatment with 4 ml/kg of 0.9% sodium chloride injection.Rabbits were sacrificed after 7 days of operation,the flap survival area was measured,the relationship between different concentrations ligustrazine and flap survival was analyzed.Results:The distal necrosis and proximal survival of flap was found after days 7 operation.With the increasing of drug dosages,the flap survival area and average survival rate increased.The flap survival area and average survival in group C and D were higher than those in group A and B(P<0.05 to P<0.01),the differences of which between group A and B,and between group C and D were not statistically significant(P>0.05).Conclusions:Appropriate dose of ligustrazine can improve the survival rate of ischemic skin flap.

       

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