Abstract: Objective:To observe the clinical effects of the application of comprehensive digestive tract poison removal in patients with severe organophosphorus pesticide poisoning(AOPP).Methods:Fifty-six severe AOPP patients were randomly divided into the control group and observation group.The control group and observation group were treated with the conventional gastric lavage,atropine,anti-infection and oxygen therapy,and comprehensive digestive tract poison removal based on the control group,respectively.The general condition,serological indexes and outcome between two groups were compared.Results:The hospitalization time,hospitalization cost,cleaning intestinal time,atropine dosage,pralidoxime chloride dosage,atropinization time and cholinesterase recovery time in observation group were significantly less than those in control group(P<0.01).After treatment,the levels of the white blood cells,creatine kinase,lactate dehydrogenase,aspartate transaminase,serum resistin and visfatin in two groups decreased significantly(P<0.01),and the decreasing degree of whose in observation group were significantly higher than those in control group(P<0.01).The mortality and incidence of severe complications in observation group were significantly lower than those in control group(P<0.01).Conclusions:The comprehensive digestive tract poison removal can clean poison,recover cholinesterase level,improve cure rate and reduce complications,which is worthy of clinical use during the treatment of severe AOPP.