Abstract: Objective:To investigate the clinical condition of pulmonary infection caused by severe head trauma infensive care unit,and observe its clinical manifestations and drug effects.Methods:The clinical diagnosis and treatment data of 110 cases with pulmonary infection caused by severe head trauma were retrospectively analyzed.Results:The incidence of pulmonary infection caused by severe head trauma was high.Eighty-eight strains of gram-negative bacteria(73.3%),26 strains of gram-positive bacteria(21.7%) and 6 strains of fungi(5.0%) were found.The sensitivities of imipenem and vancomycin were the highest.All patients were alleviated after treatment.Conclusions:The gram-negative bacteria in pulmonary infection caused by severe head trauma infensive care unit is the major pathogenic bacteria.The patient is multiple drug resistance,the use of antibiotics should be strictly control.