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    凌林, 胡郁之, 孙礼侠, 刘昌阔, 刘志刚. 结、直肠癌中MMP-2、MMP-7、MMP-9与EMMPRIN的表达及意义[J]. 蚌埠医科大学学报, 2015, 40(8): 1051-1054. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.022
    引用本文: 凌林, 胡郁之, 孙礼侠, 刘昌阔, 刘志刚. 结、直肠癌中MMP-2、MMP-7、MMP-9与EMMPRIN的表达及意义[J]. 蚌埠医科大学学报, 2015, 40(8): 1051-1054. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.022
    shu
    LING Lin, HU Yu-zhi, SUN Li-xia, LIU Chang-kuo, LIU Zhi-gang. The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in human colorectal carcinoma and its significance[J]. Journal of Bengbu Medical University, 2015, 40(8): 1051-1054. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.022
    Citation: LING Lin, HU Yu-zhi, SUN Li-xia, LIU Chang-kuo, LIU Zhi-gang. The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in human colorectal carcinoma and its significance[J]. Journal of Bengbu Medical University, 2015, 40(8): 1051-1054. DOI: 10.13898/j.cnki.issn.1000-2200.2015.08.022
    shu

    结、直肠癌中MMP-2、MMP-7、MMP-9与EMMPRIN的表达及意义

    The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in human colorectal carcinoma and its significance

      摘要
    • 摘要: 目的:探讨基质金属蛋白酶(MMP)-2、MMP-7、MMP-9和基质金属蛋白酶诱导因子(EMMPRIN)在结、直肠癌中的表达以及在结、直肠癌发展过程中的作用。方法:采用免疫组织化学法检测100例结、直肠癌组织中MMP-2、MMP-7、MMP-9和EMMPRIN的表达。结果:MMP-2、MMP-7、MMP-9和EMMPRIN在结、直肠癌组织中的表达在结、直肠癌的浸润深度、Dukes分期和有无淋巴结转移间差异均有统计学意义(P<0.01);EMMPRIN分别与MMP-2、MMP-7、MMP-9蛋白在结、直肠癌组织中的表达呈正相关关系(P<0.01)。结论:MMP-2、MMP-7、MMP-9和EMMPRIN在结、直肠癌的演进过程中可能具有一定的协同作用。

       

      Abstract: Objective:To investigate the expressions of matrix metalloproteinases-2,7 and 9(MMP-2,MMP-7 and MMP-9) and extracellular matrix metalloproteinase inducer(EMMPRIN) and their roles in the development process of colorectal carcinoma.Methods:The protein expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in 100 colorectal carcinoma tissue samples were detected by immunohistochemical method.Results:The differences of the expressions rates of MMP-2,MMP-7,MMP-9 and EMMPRIN in colorectal carcinoma tissue samples with different invasion depth,Dukes stage and lymph node metastasis were statistically significant(P<0.05).The expressions between EMMPRIN and MMP-2,MMP-7 and MMP-9 in colorectal carcinoma tissue were significant positive correlation,respectively(P<0.01).Conclusions:The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN have synergetic effects in the development of colorectal carcinoma.

       

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