视黄醇结合蛋白4和脂蛋白相关磷脂酶A2水平与冠心病及冠状动脉病变特征的相关性分析

葛玲; 程训民; 杨松; 唐杨章; 谢义民

doi:10.13898/j.cnki.issn.1000-2200.2015.08.039

视黄醇结合蛋白4和脂蛋白相关磷脂酶A2水平与冠心病及冠状动脉病变特征的相关性分析

1. 安徽省淮北市人民医院检验科, 235000;
2. 安徽省淮北市人民医院心血管内科, 235000

基金项目:

安徽省淮北市科技局资助项目(20120314)

详细信息

作者简介:
葛玲(1972-),女,主管检验师.

中图分类号: R543.3
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出版历程
- 收稿日期: 2014-07-07

The relationships between the levels of retinol binding protein 4 and lipoprotein associated phospholipase A2,and coronary heart disease and coronary artery lesion characteristics

1. Department of Clinical Laboratory, The People's Hospital of Huaibei, Huaibei Anhui 235000, China;
2. Department of Cordiovascular Medicine, The People's Hospital of Huaibei, Huaibei Anhui 235000, China

摘要

摘要: 目的:探讨血清视黄醇结合蛋白4(RBP4)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠心病的稳定性、恶化及选择性冠状动脉(冠脉)造影结果的关系。方法:将89例冠心病患者根据冠脉造影结果分为4组,造影结果正常者14例为对照组,异常者根据冠脉病变支数,分为单支病变组22例,2支病变组21例和3支病变组32例。于造影前采集血标本,酶联免疫吸附法分别定量测定4组患者Lp-PLA2、RBP4 水平。结果:3支病变组患者血清RBP4和Lp-PLA2 水平均明显高于对照组、单支和2支病变组(P<0.01),而2支病变组患者血清Lp-PLA2水平亦均显著高于对照组和单支病变组(P<0.01) ;单支病变与对照组Lp-PLA2 水平差异无统计学意义(P>0.05),单支和2支病变组及对照组血清RBP4水平差异均无统计学意义(P>0.05)。结论:冠心病患者血清Lp-PLA2、RBP4 水平与冠脉病变支数有关,可以在一定程度上反映冠脉的狭窄程度。
- 冠状动脉疾病 /
- 脂蛋白相关磷脂酶A2 /
- 视黄醇结合蛋白4 /
- 冠脉造影
Abstract: Objective:To investigate the relationships between the levels of retinol binding protein 4(RBP4) and lipoprotein associated phospholipase A2(Lp-PLA2),and stability of deterioration of coronary heart disease and selective coronary angiography results.Methods:Eighty-nine patients with coronary heart disease were divided into the control group(without vessel lesion),1 vessel lesion group,2 branches lesion group and 3 branches lesion group according to the results of coronary angiography.The levels of Lp-PLA2 and RBP4 in 4 groups before angiography were detected by enzyme-linked immunosorbent assay.Results:The levels of Lp-PLA2 and RBP4 in 3 branches lesion group were significantly higher than those in control group,1 vessel lesion group and 2 branches lesion group(P<0.01).The level of Lp-PLA2 in 2 branches lesion group was significantly higher than those in control group and 1 vessel lesion group(P<0.01).The difference of the Lp-PLA2 levels between 1 branch lesion group and control group was not statistically significant(P>0.05).The difference of the RBP4 levels between 1 branch lesion group,2 branches lesion group 2 and control group were not statistically significant(P>0.05).Conclusions:The levels of serum Lp-PLA2 and RBP4 in patients with coronary heart disease are related to the number of coronary artery lesion,which can predict the stenosis degree of coronary artery in a certain extent.
- coronary heart disease /
- lipoprotein associated phospholipase A2 /
- retinol binding protein 4 /
- coronary angiography

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