Abstract: Objective:To observe the preemptive analgesia effects of lornoxicam combined with dezocine on the rat with incision pain,and investigate its possible mechanism.Methods:Forty Wistar rats were randomly divided into the control group(without any treatment),incision pain model group(treatment with preoperative 30 min tail vein injection of saline),lornoxicam group(treatment with preoperative 30 min tail vein injection of 2 mg/kg of lornoxicam),dezocine group(treatment with preoperative 30min tail vein injection of 5 mg of lornoxicam) and lornoxicam combined with dezocine group(treatment with preoperative 30 min tail vein injection of 1 mg/kg of lornoxicam combined with 2.5 mg of lornoxicam).The pain score of rats with incision pain after operation was investigated using the cumulative pain score method.The interleukin(IL)-6 expression in the rat tail vein and cyclooxygenase(COX)-2 level in spinal cord were measured after 3h of operation.Results:The cumulative pain score in incision pain model group was significantly higher than that in lornoxicam group,dezocine group and lornoxicam combined with dezocine group(P<0.01).The cumulative pain score in lornoxicam combined with dezocine group was significantly lower than that in single drug group(P<0.01).The expressions of serum IL-6 and COX-2 in spinal cord in lornoxicam combined with dezocine group were significantly lower than that in single drug group(P<0.01).Conclusions:Lornoxicam combined with dezocine can inhibit the expressions of serum IL-6 and COX-2 in spinal cord and decrease the pain score in rat with incision pain,which plays the preemptive analgesia effects.