Abstract: Objective:To investigate the perioperative treatment method and experience in high risk benign prostatic hyperplasia(BPH) patients treated with transurethral resection of prostate(TURP).Methods:The clinical data of 65 high-risk BPH patients treated with TURP were retrospectively analyzed.The differences of the indicators in all cases between before and after operation were compared.Results:Sixty-five patients successfully withstood the TURP,and security through the perioperative period.The death case,perioperative massive hemorrhage,transurethral resection syndrome,pulmonary infection and pulmonary embolism were not found.The differences of the International prostate symptom score,QOL,Qmax and residual urine volume between before operation and after 12 months of operation were statistically significant(P<0.05).Conclusions:Individualized treatment,strict monitoring,standardize operation,thorough hemostasis and postoperatively comprehensive treatment are all important to ensure the success of operation.