Abstract: Objective:To investigate the bacterial infection distribution and drug resistance in burn wound.Methods:The bacteria from the wound secretion of different stages in 326 burn patients were cultured and identified.The drug resistance of gram negative and gram positive bacteria were detected.Results:The gram negative bacilli accounted for 69.52%(219 trains) of 315 strains of pathogenic bacteria,the proportion of pseudomonas aeruginosa was the highest(25.71%).The gram positive cocci accounted for 25.08%,the proportion of staphylococcus aureus was the highest(9.52%).The drug resistance rates of pseudomonas aeruginosa to cotrimoxazole and amikacin were the highest(97.45%) and lowest(21.12%),respectively.The drug resistance rates of bauman acinetobacter to aztreonam ＆ cefotaxime and cefoperazone/sulbactam were the highest(100.00%) and lowest(29.59%),respectively.The drug resistance rates of Escherichia coli to cotrimoxazole and imipenem were the highest(79.48%) and lowest(0.00%),respectively.The drug resistance rates of klebsiella pneumoniae to piperacillin and meropenem were the highest(88.26%) and lowest(1.42%),respectively.The drug resistance rates of staphylococcus aureus ＆ Staphylococcus aureus to penicillin and linezolid ＆ vancomycin were the highest(94.62%＆ 96.37%) and lowermost(0.00% and 0.00%),respectively.Conclusions:The Gram-negative bacteria is mainly pathogenic bacteria in burn wound infection,the drug resistance of which increases.Knowing the distribution characteristics of pathogenic bacteria and timely monitoring its drug resistance can guide the rational drug use and control infection again.