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氯氰菊酯对雄性小鼠肝脏组织的氧化损伤

张朋, 陈冲, 张凡, 杜首楠, 周礼华

张朋, 陈冲, 张凡, 杜首楠, 周礼华. 氯氰菊酯对雄性小鼠肝脏组织的氧化损伤[J]. 蚌埠医科大学学报, 2015, 40(11): 1479-1481. DOI: 10.13898/j.cnki.issn.1000-2200.2015.11.006
引用本文: 张朋, 陈冲, 张凡, 杜首楠, 周礼华. 氯氰菊酯对雄性小鼠肝脏组织的氧化损伤[J]. 蚌埠医科大学学报, 2015, 40(11): 1479-1481. DOI: 10.13898/j.cnki.issn.1000-2200.2015.11.006
ZHANG Peng, CHEN Chong, ZHANG Fan, DU Shou-nan, ZHOU Li-hua. The oxidative injury induced by cypermethrin in liver tissue of male mice[J]. Journal of Bengbu Medical University, 2015, 40(11): 1479-1481. DOI: 10.13898/j.cnki.issn.1000-2200.2015.11.006
Citation: ZHANG Peng, CHEN Chong, ZHANG Fan, DU Shou-nan, ZHOU Li-hua. The oxidative injury induced by cypermethrin in liver tissue of male mice[J]. Journal of Bengbu Medical University, 2015, 40(11): 1479-1481. DOI: 10.13898/j.cnki.issn.1000-2200.2015.11.006

氯氰菊酯对雄性小鼠肝脏组织的氧化损伤

基金项目: 

安徽省省级预防医学特色专业(皖教高[2011]5号)

安徽省教育厅自然科学研究项目(KJ2013B150)

详细信息
    作者简介:

    张朋(1989-),男,2011级学生.

  • 中图分类号: R979.8

The oxidative injury induced by cypermethrin in liver tissue of male mice

  • 摘要: 目的:研究氯氰菊酯(cypermethrin,CYP)对雄性小鼠肝脏组织的氧化损伤。方法:将40只昆明种雄性小鼠随机均分为双蒸水灌胃(阴性对照组)和CYP 5、10和20 mg/kg染毒组,连续3周经口灌胃染毒。观察小鼠肝脏脏器系数,同时检测小鼠肝组织中谷胱甘肽过氧化物酶、过氧化氢酶、总超氧化物歧化酶活性及丙二醛含量。结果:随着CYP染毒剂量的升高,CYP 5 mg/kg和10 mg/kg组小鼠肝脏脏器系数均高于阴性对照组(P<0.01和P<0.05);CYP 10 mg/kg和20 mg/kg染毒组小鼠肝脏组织中谷胱甘肽过氧化物酶与CYP 20 mg/kg组过氧化氢酶活性均低于阴性对照组(P<0.01),CYP 5 mg/kg和10 mg/kg组总超氧化物歧化酶活性均高于阴性对照组(P<0.01),CYP 20 mg/kg组小鼠丙二醛含量亦显著高于阴性对照组(P<0.01)。结论:CYP可以引起雄性小鼠肝脏组织的氧化损伤,且损伤程度与CYP剂量有关。
    Abstract: Objective: To study the oxidative injury induced by cypermethrin(CYP) in liver tissue of male mice.Methods: Forty Kunming male mice were randomly divided into the double steaming water lavage group(negative control group) and CYP at different dosage groups,the exposure dosages of CYP were 5,10 and 20 mg/kg respectively.CYP was administered to mice by gavage once daily for three weeks,then the liver index,the activities of glutathione peroxidase,catalase and total superoxide dismutase,the content of malondialdehyde in mice liver tissue were measured.Results: With the increase of CYP dosage,in the 5 mg/kg and 10 mg/kg CYP groups,the mice liver index was higher than that in the negative control group(P<0.01 and P<0.05);the activities of glutathione peroxidase in 10 mg/kg and 20 mg/kg CYP groups and catalase in the 20 mg/kg CYP group were decreased compared with the negative control group(P<0.01),the activities of superoxide dismutase were decreased in 5 mg/kg and 10 mg/kg CYP groups(P<0.01).Malondialdehyde content was increased in the 20 mg/kg CYP group compared with the negative control group(P<0.01).Conclusions: Cypermethrin can induce the oxidative damage in male mice liver tissue.
  • [1] 马萍,陈姣娥,甘亚萍.氯氰菊酯对小鼠睾丸组织的氧化损伤和维生素E的抗氧化作用[J].环境与职业医学,2013,30(6):465-469.
    [2] 马萍,张忠杰,焦铭,等.氯氰菊酯对小鼠脑细胞的氧化损伤及维生素E的抗氧化作用[J].中国环境科学,2013,33(7):1323-1327.
    [3]

    Li YF,Pan C,Hu JX,et al.Effects of cypermethrin on male reproductive system in adult rats[J].Biomed Environ Sci,2013,26(3):201-208.

    [4] 安丽,蔡原,吕相征,等.高效氯氰菊酯对雄性小鼠免疫功能的影响[J].中国公共卫生,2002,18(4):444-445.
    [5] 付志燕,杜春荟,姚扬,等.高效氯氰菊酯对大鼠海马CA3区神经元电压门控钾通道的影响[J].生理学报,2007,59(1):63-70.
    [6]

    Dahamna S,Bencheikh F,Harzallah D,et al.Cypermethrin toxic effects on spermatogenesis and male mouse reproductive organs[J].Commun Agric Appl Biol Sci,2010,75(2):209-216.

    [7]

    Chi HJ,Kim JH,Ryu CS,et al.Protective effect of antioxidant supplementation in sperm-preparation medium against oxidative stress in human spermatoza[J].Human Reproduction,2008,23(5):1023-1028.

    [8] 邱俏檬,廖心军,卢中秋,等.二甲基甲酰胺对小鼠肝功能、氧化酶及抗氧化酶的影响[J].温州医学院学报,2006,36(3):198-201.
    [9] 马茜,慕家琪,杨遂群,等.贺兰山紫蘑多糖联合5-Fu对H22荷瘤小鼠体内抗氧化酶系统的影响[J].食品工业科技,2013,34(14):342-345.
    [10]

    Wang XZ,Liu SS,Sun Y,et al.Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress[J].Theriogenology,2009,72(5):599-611.

    [11] 李静,李燕芳,潘晨,等.氯氰菊酯对大鼠睾丸组织氧化应激的影响[J].环境与健康杂志,2011,29(8):739-740.
    [12] 马萍,秦龙娟,张亚然,等.高效氯氰菊酯对小鼠肝细胞的氧化损伤[J].环境科学学报,2012,32(3):757-761.
    [13]

    Jin YX,Wang LG,Ruan ML,et al.Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice[J].Chemosphere,2011,84(1):124-130.

    [14] 马萍,周慧芬,陈姣娥,等.维生素E对氯氰菊酯致小鼠肺组织氧化损伤的拮抗[J].环境与健康杂志,2013,30(3):207-210.
    [15] 王瑞龙,陈玉明,徐军,等.氯氰菊酯对唐鱼肝和腮组织超氧化物歧化酶(SOD)活性的影响[J].水产科学,2003,22(6):5-7.
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出版历程
  • 收稿日期:  2014-10-30

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