Abstract: Objective: To observe the clinical effects of micro-feeding combined with massage therapy in improving the feeding intolerance in preterm infants.Methods: Sixty-six preterm infants were randomly divided into the observation group and control group(33 cases each group).Two groups were treated with keeping warm,monitoring electrocardiogram,preventing infection,maintaining homoiostasis,supporting parenteral nutrition and dealing with symptoms.The control group were fed using milk bottle,and the observation group were additionally fed with micro-feeding.The preterm infants were treated with non-nutritive sucking or eyedropper feeding,indwelling gastric tube feeding and massage therapy within 24 hours after birth.The time of the bloating,gastric retention disappear and recovering birth weight,and incidence of feeding intolerance between two groups were compared.Results: Compared with the control group,the time of the bloating,gastric retention disappear and recovering birth weight,and incidence of feeding intolerance in the observation group were significantly short and low,respectively(P<0.01).Conclusions: Micro-feeding combined with massage therapy can significantly reduce the incidence of feeding intolerance in premature infants,and be benefit to meet the total enteral nutrition and growth demand in preterm infants as soon as possible.Appropriate feeding method has great significance in improving the clinical treatment level of preterm infants in primary hospitals.