Abstract: Objective: To evaluate the application value of high-frequency ultrasound imaging in the diagnosis of thyroid carcinoma.Methods: The ultrasonograms data in 309 thyroid cancer nodules(278 cases) confirmed by surgery and pathology were retrospectively analyzed.The sonographic features between different pathological types and the same pathological type of thyroid carcinoma were compared.Results: Among the 278 thyroid carcinoma patients,unifocal in 259 cases and multifocal in 19 cases were found,the papillary carcinoma in 264 cases,follicular thyroid carcinoma in 9 cases,medullary carcinoma in 4 cases and undifferentiated carcinoma in 1 case were identified,the hypoechoic nodules in 241 cases,mixed cystic and solid nodule in 28 cases and slightly high level echo nodule in 9 cases were identified.Two hundred and sixty-four papillary carcinoma patients included 78 cases of small papillary carcinoma and 186 cases of large papillary carcinoma.Among the small papillary carcinoma patients,the blood signal in internal and edge of 45 cases,and no significant blood signal in 33 cases were showed,and the 51 cases with small calcification were found,the calcification rate of which was 65.4%.Among the large papillary carcinoma patients,the blood signal in internal and edge of 184 cases and no significant blood signal in 2 cases were showed,the difference of which was statistically significant(P<0.01),and the 84 cases with small calcification were found,the calcification rate of which was 65.4%,the difference of which was statistically significant(P<0.01).Conclusions: Knowing the characteristics of ultrasound performance of various types of thyroid carcinoma can reduce its missed diagnosis and misdiagnosis,which can provide the valuable information in taking reasonable clinical treatment.