Abstract: Objective:To analyze the clinical efficacy of the D3 radical surgery under laparoscopy in the treatment of right colon cancer.Methods:Ninety patients with right colon cancer in our department from March 2009 to March 2013 were randomly divided into the observation group and control group.The observation group were treated with the D3 radical surgery under laparoscopy,and the control group were treated with the traditional open surgery.The general surgery condition,score of postoperative quality of life,postoperative 1,3-year disease-free survival and overall survival rates and postoperative complication in two groups were compared.Results:The operative time,blood loss,recovery time of hospital stay intestinal exhaust in observation group were significantly shorter than those in control group(P<0.01).The scores of the postoperative physiological function,psychological function,emotional function and social function in observation group were significantly lower than those in control group(P<0.01).The 3-year disease-free survival rate,and 1,3-year overall survival rate in observation group were significantly higher than those in control group(P<0.05 to P<0.01).The difference of the postoperative wound infection rate between two groups was not statistically significant(P>0.05).Conclusions:Compared with traditional open surgery,the D3 radical surgery under laparoscopy in the treatment of right colon cancer is fewer trauma,good effect,less postoperative recurrence rate and high security,which is worthy of clinical application.