Abstract: Objective:To evaluate the safety and effectiveness of laparoscopic myomectomy combined with uterine artery occlusion in the treatment of uterine fibroids.Methods:Eighty uterine fibroids patients treated with laparoscopic myomectomy were divided into the joint uterine artery occlusion group(blocking group) and non-jiont uterine artery occlusion(control group).The intraoperative condition and postoperative recovery between two groups were compared.Results:All patients were cured and no conversion to open surgery.The operative time,intraoperative blood loss,stomach exhaust time,postoperative hospital stay and postoperative pain scores in blocking group were significantly less or better than those in control group(P<0.01).The differences of the IL-1,IL-6 and TNF-α levels before operation between two groups were not statistically significant(P>0.05),the IL-1,IL-6 and TNF-α levels after 3 days of operation in blocking group were significantly less than those in control group(P<0.01).During the period of following-up,the menorrhagia relieve rate in blocking group was higher than that in control group(P<0.05),but the menstrual volume and fibroid recurrence rate in blocking group were significantly lower than those in control group(P<0.01 and P<0.05).Conclusions:Patients treated with laparoscopic uterine artery occlusion is good toleration,less bleeding,little inflammatory and low recurrence rate during the period of following-up,which is worthy of application.