Abstract: Objective:To investigate the effects of the nursing intervention on the moderate and advanced ovarian carcinoma patients treated with abdominal hyperthermia combined with TP program. Methods:Two hundred and thirty-four moderate and advanced ovarian carcinoma patients treated with abdominal hyperthermia combined with TP program were divided randomly into the control group and intervention group(117 cases each group). The control group were conventionally nursed. In intervention group before, during and after chemotherapy and hyperthermia, the considerations were prompted, the vital signs were paid close attention to, and the relevant nursing was implemented. The short-term effects, adverse reactions and long-term survival rate between two groups were analyzed. Results:The short-term total effective rate in the intervention group(69.2%) was significantly higher than that in the control group(51.2%)(P<0.01). The differences of the incidence rates of leucopenia and anaphylaxis between two groups were not statistically significant(P>0.05). The incidence rates of nausea and hepatic injury in the intervention group were significantly lesser than those in the control group(P<0.05). The one-year and three-year survival rates in the intervention group(86.3% and 54.7%) were significantly higher than those in the control group(72.6% and 41.9%), respectively(P<0.05). Conclusions:The reasonable nursing intervention in moderate and advanced ovarian carcinoma patients treated with abdominal hyperthermia combined with TP program can improve the short-term effects and long-term survival rate, and decrease the complications.