Abstract:
Objective: To Study on the pathological lesion in Balb/c mice infected with H37Ra.
Methods: The mice were divided into control group and model group infected with
Mycobacterium tuberculosis. Balb/c mice was injected via the tail vein with attenuated
Mycobacterium tuberculosis H37Ra (1×10
6 CFU/mouse). After infection, living bacteria, organ weight index of lung or spleen, and histopathological lesion were detected after 7, 14, and 21 days of infection.
Results: Compared with the group of control, the organ coefficient of spleen increased statistically after 14 days or 21 days of infection(
P<0.01 and
P<0.05);The number of living bacteria in spleen tissue of infected mice increased with the days of infection and was higher in spleen tissue than that in lung tissue. Tuberculosis-like lesions were observed in spleen and lung tissue of infected mice model.
Conclusions: Attenuated
Mycobacterium tuberculosis H37Ra could induced tuberculosis-like lesions in Balb/c mouse via the tail vein injection.