Abstract: Objective: To investigate the association of indel polymorphisms of BRM-741 and BRM-132 with the susceptibility of esophageal squamous cell carcinoma (ESCC) in Chinese Han population. Methods: The genotype distribution of BRM-741and BRM-1321 in 343cases of ESCC and 362 healthy controls whose gender, age and other demographic characteristics were matched with the frequency of the ESCC cases was analyzed in a case-control study by using polymerase chain reaction-polyacrylamide gel electrophoresis method. Logistic regression model was used to evaluate the association between polymorphisms and ESCC susceptibility. Results: There was no significant association between BRM-741 and ESCC(P>0.05). However, there was a significant association between BRM-1321 and ESCC susceptibility(P<0.01). The insertion/insertion genotype was associated with an increased risk of ESCC compared with the deletion/deletion genotype of BRM 1321 (OR=1.94, 95%CI=1.11-3.38). The insertion allel was associated with an increased risk of ESCC compared with the deletion allel of BRM 1321 (OR=1.35, 95%CI=1.07-1.71). Conclusions: The polymorphism in BRM-1321 is associated with ESCC susceptibility, but no significant association is observed between the polymorphism in BRM-741 and ESCC incidence in Chinese Han population.