Abstract: Objective: To explore the clinical effects of Liss and GSH in the treatment of distal femur fracture. Methods: According to the AO typing, patient's physical condition and local soft tissue situation, the type A1, A2, A3, C1 and C2 in 19 patients(GSH group) and type A1, A2, A3, C1, C2 and C3 in 18 patients(Liss group) were treated with GSH and Liss, respectively. The fracture healing time and HSS scores between two groups were compared. Results: All cases were followed up. The fractures were anatomically reset, and the incision was smooth healed. The heal time of fractures in GSH and Liss group were(5.0±1.2) and(4.8±1.17) months, respectively, the difference of which was not statistically significant(P>0.05). The HSS knee scores in GSH and Liss group were(89.4±10.6) and(89.9±11.11), respectively, the difference of which was not statistically significant(P>0.05). Conclusions: The treatment of distal femur fracture with Liss and GSH can achieve good effects, the difference of which is no obvious.