Abstract: Objective: To compare the effects of two different anaesthetic methods on the anesthesia recovery of patients after supratentorial tumor resction. Methods: Sixty-six patients were randomly divided into the propofol-remifentanil(PR group) and sevoflurane-sufentanil(SS group). The PR group and SS group were anaesthetized using propofol-remifentanil and sevoflurane-sufentanil under the bispectral index(BIS) monitor, respectively. The time of the spontanous breathing recovering, extubation and response in two groups were evaluated after operation. The time at Simplified Sedation Score(SSS) less than or equal to 1, Glasgow Coma Scale(GCS) equal to 15, Pain Visual Analogue Scale(PVAS) less than 4, Mini-mENTAL sTATE(MMS) equal to 30 and Aldrete Score(AS) equal to 10 in two groups were recorded. Results: The differences of the spontanous breathing recovering time, extubation time and response time between two group were not statistically significant(P>0.05). The time at the postoperative AS equal to 10, MMS equal to 30 and GCS equal to 15 in SS group was sooner than those in PR group(P<0.05). The differences of the time at PVAS less than 4 and SSS less than or equal to 1 between two groups were not statistically significant(P>0.05). Conclusions: The anesthesia recovery time between the propofol-remifentanil and sevoflurane-sufentanil in patients after supratentorial tumor resction under the bispectral index monitor has no significant difference. The sevoflurane-sufentanil can improve the neural function recovery of patients.