Abstract: Objective:To investigate the clinical efficacy of Fufangkushen injection combined with chemotherapy in the treatment of advanced lung adenocarcinoma.Methods:Eighty-seven patients with advanced lung adenocarcinoma were randomly divided into the Fufangkushen injection combined with chemotherapy group(observation group, 44 cases) and chemotherapy alone group(control group, 43 cases).The effective rate, progression-free survival and quality of life in two groups were observed.Results:The total effective rates in observation group and control group were 36.4% and 30.2%, respectively, the difference of which was not statistically significant(P>0.05).The difference of the progression-free survival between two groups was not statistically significant(P>0.05).The score of quality of life in observation group was better than that in control group(P<0.01).The incidence of adverse reaction in observation group was lower than that in control group(P<0.05 to P<0.01).Conclusions:Fufangkushen injection combined with chemotherapy treatment can not improve treatment response and prolong survival time, but which can improve the quality of life and alleviate the adverse reaction of chemotherapy.