Abstract: Objective:To investigate the effects of the Xingnaojing injection on coagulation and nerve function in patients with acute cerebral infarction.Methods:Ninety patients with acute cerebral infarction were randomly divided into the observation group and control group(45 cases each group).The control group were treated with routine method, the observation group were additionally treated with Xingnaojing injection based on routine method.Results:The number of CD34⁺ cell and white blood cell in the observation group were the highest after 6 days of treatment, which was obviously higher than those at other time-points(P<0.01).The differences of platelet count, and levels of alanine aminotransferase, serum creatinine and D-dimer in observation group at all time-points were not statistically significant(P>0.05).The differences of activated partial thromboplastin time, prothrombin time and fibrinogen level in observation group at different time-points were statistically significant(P<0.01).The NIHSS scores in observation group after 2 and 3 months of treatment were significantly lower than those in control group(P<0.01).Conclusions:The Xingnaojing injection can effectively regulate the coagulation and nerve function, and improve the short-term effects in patients with acute cerebral infarction.