Abstract:
Objective:To analyze the resistant characteristics of ESBLs
Escherichia coli produced by urine culture, investigate its antibacterial activity
in vitro and compare with other antibacterial drugs.
Methods:A total of 821 strains were cultured from the strain library, the ESBLs
Escherichia coli produced by urine culture were screened according to the phenotype of ESBLs, the antibacterial activities
in vitro of 15 antimicrobial agents, including fosfomycin, were detected by K-B method.
Results:Among the 821
Escherichia coli strains, the sensitivities of the 465 ESBLs
Escherichia coli strains produced by urine culture to imipenem were high(91.4%), following by fosfomycin(88.0%), the sensitivities of which to levofloxacin, penicillin and cephalosporin were low.
Conclusions:The sensitivity of carbapenem is the highest drug, the antibacterial activity
in vitro of fosfomycin to ESBLs
Escherichia coli produced by urine culture is good, which has certain clinical value.