Abstract: Objective: To explore the relationship between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and glucose level in initial diagnosis type 2 diabetes patients(T2DM). Methods: Sixty-eight initial diagnosis T2DM patients were divided into the observation group, and fifty-six non-diabetic healthy people with the same age, sex, waist circumference and BMI as the observation group were set as the control group. The levels of fasting blood glucose(FBG), glycosylated hemoglobin A1c(HbA1c), serum lipid and LOX-1 in two groups were tested. The relationship between LOX-1 and HbA1c was analyzed. Results: The levels of FBG, HbA1c, LOX-1 and LDL-cholesterol in observation group were significantly higher than those in control group(P<0.01). The level of HbA1c was positive correlation with LOX-1(P<0.01), and the level of lipids was not correlation with the LOX-1(P>0.05). Multivariate linear stepwise regression analysis showed that the HbA1c level increasing was the independent risk factor of the LOX-1 level increasing(P<0.01). Conclusions: High blood glucose may directly lead to the expression of LOX-1 increasing, which can initiate the atherosclerosis of diabetes.