Abstract: Objective: To investigate the effects of 5E rehabilitation model on anxiety, depression and knee function of patients with lower limb burn. Methods: Eighty-eight patients with lower limb burn were randomly divided into the observation group and control group(44 cases each group). The control group were nursed with routine rehabilitation measure. On this basis, the observation group were additionally nursed with 5E rehabilitation model(including encouragement, education, exercise, employment and evaluation). The anxiety, depression and knee function between two groups were compared. Results: The scores of the anxiety and depression in observation group were obviously lower than those in control group(P<0.01). The moderate and severe anxiety and depression rate in observation group were obviously lower than those in control group(P<0.01). The active and passive ranges of motion in observation group were obviously higher than those in control group(P<0.01). The scores of stair activity, functional independence measure and muscle force in observation group were obviously higher than those in control group(P<0.01). Conclusions: Compared with the routine rehabilitation model, the 5E rehabilitation model can effectively improve the anxiety and depression, range of joint motion and knee function in patients with lower limb burn.