Abstract: Objective:To establish a three-dimensional(3D) visualization model of cerebral superior frontal sulcus in a healthy adult people using MR image for exploring the anatomical characteristics of the superior frontal sulcus and application in brain stereotactic surgery.Methods:The brain slice MR scanning in one healthy adult female was harvested,the data of which was inputted to 3D-Doctor software.The 3D visualization model was reconstructed,and marked with different colors by the manual partition method.Results:The 3D visualization schema graph of cerebral superior frontal sulcus was constructed,which showed successfully the three-dimensional shape of cerebral superior frontal sulcus,lateral ventricle,brain surface and their structural relationships with surrounding brain.Conclusions:The 3D visualization model of cerebral superior frontal sulcus has an important value in the identification of the anatomical structure of superior frontal sulcus and design of stereotactic surgery.