Abstract: Objective:To measure the serum levels of insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGF-BP3) in patients with type 2 diabetic nephropathy,and explore its correlation with type 2 diabetic nephropathy.Methods:According to the results of the urinary albumin excretion rate(UAER),86 patients with type 2 diabetes were divided into the simple diabetes group(SDM group,33 cases),early diabetic nephropathy group(EDN group,28 cases) and clinical stage of nephropathy group(CDN group,25 cases).The levels of the IGF-1,IGF-BP3,UAER and other indicators were detected,which was used to analyze the correlations of IGF-1 and IGF-BP3 with diabetic nephropathy.Results:The serum levels of IGF-1 and IGF-BP3 and UAER in CDN group were higher than those in SDM group and CDN group(P<0.01),the serum levels of IGF-1,IGF-BP3 and UAER in CDN group were higher than those in EDN group(P<0.01).The IGF-1 was positive correlation with the creatinine,urea nitrogen,UAER and IGF-BP3,respectively(P<0.01),the IGF-1 was correlation without age and glycosylated hemoglobin(P >0.05),and was negative correlation with fasting plasma glucose(P<0.01).Conclusions:The serum levels of IGF-1 and IGF-BP3 are related to the occurrence and development of type 2 diabetic nephropathy,which can be used as one of the early diagnosis index of diabetic nephropathy.