Abstract: Objective:To analyze the serum levels of vascular endothelial growth factor(VEGF),osteoprotegerin(OPN) and tumor markers in patients with different outcomes after transcatheter arterial immune chemoembolization(TAICE),and its significance in evaluating postoperative effects.Methods:The clinical efficacy,and the levels of VEGF,OPN and tumor marker in 41 patients with moderate or advanced liver cancer were evaluated after TAICE.Results:The complete remission(CR) in 4 cases(9.8%),partial remission(PR) in 31 cases (75.6%),SD in 4 cases(9.8%) and PD in 2 cases(4.9%) were identified after operation,the total effective rate was 85.4%.The levels of OPN and VEGF in PR patients were significantly higher than those in CR patients(P<0.01).Compared with the CR and PR patients,the levels of OPN and VEGF in SD patients increased significantly(P<0.01).Compared with the CR,PR and SD patients,the levels of OPN and VEGF in PD patients increased significantly(P<0.01).Compared with the CR patients,the levels of AFP,CEA and AFU in PR patients increased significantly(P<0.05 to P<0.01).Compared with the CR and PR patients,the levels of AFP and AFU in SD patients increased significantly(P<0.01).Compared with the CR patients,the level of CEA in SD patients increased significantly(P<0.05).Compared with the CR,PR and SD patients,the levels of AFP,CEA and AFU in PD patients increased significantly(P<0.01).Conclusions:The treatment of hepatocellular carcinoma with TAICE has better clinical effects.The VEGF and OPN involve in development of hepatocellular carcinoma,which are the important indicators in evaluating the clinical efficacy.