Abstract: Objective:To explore the relationships between homocysteine(Hcy),C reactive protein(CRP) and hypertensive disorder complication pregnancy(HDCP).Methods:One hundred and twenty-six pregnant woman with HDCP(including 69 cases with gestational hypertension,31 cases with mild preeclampsia and 26 cases with severe preeclampsia) and 119 normal late pregnancy women were divided into the HDCP group and control group,respectively.The levels of Hcy and CRP in two groups were detected and compared.Results:The plasma levels of Hcy and CRP in HDCP group were higher than those in control group(P<0.01).The plasma levels of Hcy and CRP in three subgroups were higher than those in the control group(P<0.01).The plasma levels of Hcy and CRP in the 3 subgroups increased gradually with the aggravation of disease(P<0.01).The plasma levels of Hcy and CRP were significantly positively correlated with the degree of HDCP(P <0.01).Conclusions:The plasma levels of Hcy and CRP in HDCP pregnancy women increase with the development of disease,which is the risk factor of HDCP.The plasma levels of Hcy and CRP in HDCP should closely be pay attention to,which can guide the prevention diagnosis and treatment of HDCP.