Abstract: Objective: To investigate the clinical effects of the intensive care unit(ICU) optimization on cerebral resuscitation in patients with post-cardiac arrest syndrome(PCAS).Methods: Ninety patients with PCAS were randomly divided into the control group and observation group(45 cases each group).Two groups were treated with routine ICU nursing,while the observation group were additionally treated with optimization scheme.The clinical indicators,heart function improvement,nerve function recovery,mortality and incidence of complications between two groups were compared.Results: The differences of the ventilation and hospitalization time in intensive care unit and global end diastolic volume index between two groups were not statistically significant(P>0.05).The cardiac index in observation group after treatment was significantly lower than that in control group(P<0.01),while the good rate of nerve function recovery and mortality in observation group were significantly higher and lower than that in control group,respectively(P<0.05 and P<0.01).The difference of the incidence of complications between two groups was not statistically significant(P>0.05).Conclusions: The intensive care unit optimization treatment can significantly improve the cardiac function and nerve function,and reduce the mortality of the PCAS patients.