Abstract: Objective: To explore the analgesia effects of dexmedetomidine combined with ropivacaine block after total abdominal hysterectomy.Methods: Seventy patients scheduled by total hysterectomy were radomly divided into the control group and observation group(36 cases each group).The control group were blocked by ropivacaine transabdominal fascia plane guided by ultrasound,the observation group were blocked by dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound.Results: The pain scores in observation group at postoperative 4 h,12 h and 24 h were significantly lower than those in control group(P<0.01).The differences of the scores at postoperative 4 h,12 h and 24 h between two groups were statistically significant(P<0.01).The complications(including dizziness,nausea,vomiting,drowsiness,respiratory depression,urinary retention) in observation group at postoperative 24 h were significantly less than those in control group(P<0.05).The overall analgesic satisfaction scores in observation group and control group were was statistically significant(P<0.01).Conclusions: The dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound after total hysterectomy can effectively play the analgesia and sedation effects,reduce the complications and improve satisfaction of patients.