Abstract: Objective: To investigate the clinical effects of modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in the treatment of refractory sinusitis(RRS).Methods: Forty-two RRS patients were treated with modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection.Among the patients,26 cases with nasal septum deflection were treated with traditional correction resection under endoscopy,and 16 cases with allergic rhinitis were treated with the mucosa electrocoagulation.The clinical symptoms and quality of life in all patients between before and after treatment were compared.Results: The visual analogue scale(VAS) scores of nasal obstruction,rhinorrhea,olfactory loss or disorder and facial pain or oppress sense in of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The total scores of SNOT-20,somatic symptom score and mental function score of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The nasal mucocilia transfer rate(MTR) value of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).After the operation,the healing in 17 cases(40.48%),improvement in 21 cases(50.00%) and ineffectiveness in 4 cases(9.52%) were identified.Conclusions: The modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in treating the RRS can significantly improve the clinical symptoms,the effect of which is good.