Abstract: Objective: To analyze the metabolic disorders index in patients with type 2 diabetes mellitus complicated with kidney disease,and explore the characteristics of metabolic disorders in type 2 diabetic nephropathy patients.Methods: The clinical data of 131 cases with type 2 diabetes were analyzed,and the patients were type 2 diabetes complicated without kidney disease(T2DM group) and type 2 diabetes mellitus complicated with kidney disease group(DKD group) according to the urine and kidney function.The levels of the glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),blood uric acid and creatinine in two groups were detected and analyzed.Seventy-seven DKD patients were divided into the high uric acid group and normal uric acid group according to the level of uric acid,and the levels of glycosylated hemoglobin,blood lipid and creatinine between two groups were compared.Results: The levels of the serum TC,LDL-C,creatinine and uric acid in patients with type 2 diabetic nephropathy group were significantly higher than those in patients without kidney disease(P<0.01),but the level of HDL-C level was lower than that in control group(P<0.05).Among the type 2 diabetic nephropathy patients,the levels of TC,LDL-C,and creatinine in high uric acid group were significantly higher than those in normal uric acid(P<0.01),but the level of HDL-C was significantly lower(P<0.05),and the difference of the level of HbA1c between two groups was statistically significant(P>0.05).Conclusions: The occurrence of diabetic nephropathy is associated with the metabolic disorder of blood sugar,blood lipids and uric acid.The active controling the levels of the blood sugar,blood lipids and uric acid of patients with diabetes has important clinical significance in preventing and treating diabetic nephropathy.