抗环瓜氨酸肽抗体在类风湿关节炎诊断中的应用研究

高金芳; 施丹; 张莉

doi:10.13898/j.cnki.issn.1000-2200.2016.11.033

抗环瓜氨酸肽抗体在类风湿关节炎诊断中的应用研究

The application research of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis

摘要

摘要: 目的：研究抗环瓜氨酸肽（CCP）抗体检测在类风湿关节炎（RA）诊断中的临床意义。方法：采用ELISA法检测RA患者（RA组）、非RA的其他风湿病患者（对照组Ⅰ）和健康对照组（对照组Ⅱ）的抗-CCP抗体，采用免疫比浊法检测各组的类风湿因子（RF），分析并比较抗-CCP抗体和RF在各组中的分布。结果：抗-CCP抗体在RA组、对照组Ⅰ和对照组Ⅱ的阳性率分别为52.0%、6.0%和0.0%，其在RA组的阳性率均明显高于对照组Ⅰ和对照组Ⅱ（P<0.01）。对照组Ⅰ患者血清抗-CCP抗体和RF阳性率差异有统计学意义（P<0.01）。RA组患者血清抗-CCP抗体与RF无相关关系（P>0.05）。结论：抗-CCP抗体是RA的一种较特异的诊断指标；临床上应用抗-CCP抗体检测，可以提高RA的诊断率。

Abstract: Objective: To evaluate the role of anti-cyclic citrullinated peptide(anti-CCP) antibody in the diagnosis of rheumatoid arthritis(RA).Methods: The present study comprised of clinically diagnosed RA patients(RA group),non-RA diseases(control groupⅠ) and healthy subjects(control groupⅡ).To compare the correlation among anti-CCP and rheumatoid factor(RF),they were analyzed by ELISA and immunoturbidimetric assay respectively.Results: The positive rate of anti-CCP antibody was 52.0%,6.0% and 0.0% respectively in RA group,control groupⅠ and control groupⅡ,with significant difference(P<0.01).There was no correlation between anti-CCP antibody and RF(P>0.05).Conclusions: Anti-CCP antibody is a relatively specific diagnosis of RA and the application of anti-CCP antibody in clinic can improve the diagnosis of RA.

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