Abstract: Objective: To investigate the safety and effects on the comfort level of patients of the first compression time of TR Band after Transradial coronary intervention(TRI).Methods: One hundred patients treated with TR band hemostasis after TRI were divided into the observation group and control group according to the random number table(50 cases each group).The observation group were decompressed after postoperative 2 h,1 time each 2 h,discharge 2 mL each time for 3 times,and were completely discharged within 10 h.The control group were decompressed after postoperative 4 h,1 time each 2 h,discharge 2ml each time for 3 times,and were completely discharged within 12 h.The hemostasis effects,comfort level of patients,oxygen saturation(SpO₂) of transcutaneous oppression side of forefinger and complications of oppression location between two groups were observation and compared.Results: Two decompression methods can effectively stop bleeding,the difference between the two groups was not statistically significant(P>0.05),the SpO₂ level was within the normal range after 2 h of operation(P>0.05).The difference of the comfort level after 2 h of operation between two groups was not statistically significant(P>0.05);but the differences of the levels comfort and SpO₂ after 4 h of operation between two groups were statistically significant(P<0.01).The differences of the incidences of ecchymosis,local blisters,cyanosis and numbness at different postoperative time between two groups were statistically significant(P<0.05 to P<0.01).Conclusions: The first decompression time of TR Band should be advanced to the postoperative 2 h,and the decompression time should be within the postoperative 10 h,which can reduce postoperative complications,and increase the comfort of patien.