Abstract: Objective: To explore the correlation between clinical objective biochemical indexes and liver tissue pathology chronic hepatitis B(CHB).Methods: The clinical data of liver tissue pathology and objective biochemical indexes in 468 CHB were collected from 2013 to 2015,the correlation of which were analyzed.Results: The inflammatory activity included G2 stage(70.1%,maxium),G4 stage (1.9%) and G0 stage(0.0%,minimum).Fibrosis stage included S2 stage(40.6%,maxium),S0 stage(9.0%) and S4 stage(4.3%,minimum).The inflammatory activity in different age patients was positively correlated with the fibrosis stage(P<0.05).With the increasing of age,the degree of liver inflammation and fibrosis gradually increased.Different lg10HBV-DNA was not corelated to the inflammatory activity(P>0.05),and positively correlated with fibrosis stage(P<0.05).Different levels of HBsAg and HBeAg were negatively correlated with the pathological inflammatory activity and fibrosis stage(P<0.05).The differences of the AST,ALB,GGT and PT between different inflammatory activity patients,and AST and GGT between different fibrosis stage patients were statistically significan(P<0.01).Conclusions: The clinical objective index in patients with CHB is correlation with the liver tissue pathology to some extent.The clinical objective index of patients can reflect the liver function and illness condition of patients to a certain extent,which can help to understand the condition of patient who cannot accept liver biopsy,and choose the antiviral treatment.