Abstract: Objective:To investigate the causes of restlessness,and observe the respiratory rate(RR),blood oxygen pressure(PaO₂) and mean arterial pressure(MAP) after the use of sedative drugs in craniocerebral trauma patients.Methods:One hundred patients with craniocerebral trauma were divided into the observation group and control group according to the order of admission(50 cases each group).The reasons of restlessness in two groups were analyzed.The control group were treated with propofol combined with midazolam,and the observation group were treated with dexmedetomidine sedation.Results:Compared before treatment,the RR and MAP in two groups significantly decreased,but the PaO₂ significantly increased after treatment.Compared with the control group,the decreasing degree of the RR and MAP during treatment and after treatment was small,but the increasing degree of PaO₂ was mang in observation group(P<0.01).The effective rate of agitation control in observation group(100.00%) was significantly better than that in control group(P<0.01).Conclusions:The calming effect of dexmedetomidine on craniocerebral trauma patients is obvious,which does not impact on the conscious process and inhibit breathing,and is an ideal sedative drug.